EVALUATION OF TRANSDERMAL TRANSPORT AND CONCURRENT CUTANEOUS HYDROLYSIS OF TIMOLOL PRODRUG FOR THE TREATMENT OF INFANTILE HEMANGIOMAS

Evaluation of Transdermal Transport and Concurrent Cutaneous Hydrolysis of Timolol Prodrug for the Treatment of Infantile Hemangiomas

Infantile hemangiomas (IH) leave sequelae after involution.Topical application of timolol COENZYME Q10 100MG maleate (TM) is the mainstream treatment for superficial lesions but is limited by its low penetrable properties.We aimed to develop a superior skin permeation drug while maintaining the therapeutic properties of timolol.We predict that this

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Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies

Abstract Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the worst prognoses, with no targeted therapeutic strategies currently available.Regulated cell death (RCD), also known as programmed cell death (PCD), has been widely reported to have numerous links to the progression and therapy of many types of human ca

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Impact of a modified progressive Copenhagen adduction exercise programme on hip adduction strength and postexercise muscle soreness in professional footballers

Background Reduced hip adduction strength has been identified as a key predisposing factor in developing hip and groin injuries.The Copenhagen adduction programme has been shown to increase hip adduction strength in semiprofessional footballers but can cause muscle soreness.Therefore, a modified progressive Copenhagen adduction (MPCA) programme has

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